Talking Sleep Season 5 | Episode 10

More than chin music: How a new signal can assess sleep-disordered breathing

Dr. Jean-Louis Pépin and Dr. Atul Malhotra, GUESTS

In this episode of Talking Sleep, we are joined by Dr. Jean-Louis Pépin and Dr. Atul Malhotra, who talk about how the signal derived from mandibular jaw movements during sleep can be an alternative measurement of respiratory effort in patients being evaluated for suspected sleep apnea. We will focus on the scientific basis and clinical implications of this new signal. (28:55)

Dr. Jean-Louis Pépin

Dr. Jean-Louis Pépin is a professor of clinical physiology at University Grenoble-Alpes in France. He directs a translational research team (INSERM U1300) examining cardiometabolic consequences of intermittent hypoxia at molecular and cellular levels and in rodent models. He has led clinical trials and real-world observational studies evaluating CPAP and lifestyle interventions with a specific interest for new management pathways including digital medicine and artificial intelligence.

Dr. Atul Malhotra

Dr. Atul Malhotra is the Farrell Presidential Chair of Respiratory Medicine and research chief of pulmonary, critical care, sleep medicine and physiology at the University of California, San Diego. He is a past president of the American Thoracic Society, and he is active clinically and has published extensively on sleep apnea and other topics.

Episode Resources

  1. Pepin JL, Le-Dong NN, Cuthbert V, Coumans N, Tamisier R, Malhotra A, Martinot JB. Mandibular movements are a reliable noninvasive alternative to esophageal pressure for measuring respiratory effort in patients with sleep apnea syndrome. Nat Sci Sleep. 2022;14:635-644.
  2. Martinot JB, Le-Dong NN, Malhotra A, Pépin JL. Respiratory effort during sleep and prevalent hypertension in obstructive sleep apnoea. Eur Respir J. 2023;61(3):2201486.
  3. Martinot JB, Le-Dong NN, Borel AL, Tamisier R, Malhotra A, Pépin JL. Respiratory effort during sleep and the rate of prevalent type 2 diabetes in obstructive sleep apnoea. Diabetes Obes Metab. 2023 Jun 13.