Season 6 | Episode 6


While CPAP devices are similar across manufacturers, there are more significant differences in the advanced modalities of ventilatory support. Dr. Lisa Wolfe is well known for her granular knowledge of mechanical ventilation, including noninvasive ventilation (NIV). She discusses some aspects of NIV that may become pertinent as both sleep labs and patients transition off devices recalled by Philips Respironics. She also addresses concerns related to patients who have complex conditions such as chronic obstructive pulmonary disease (COPD), obesity hypoventilation syndrome, and neuromuscular disease.

Lisa Freeman Wolfe, MD, is a professor of medicine and neurology in the Ken and Ruth Davee Department of Neurology at the Northwestern Medicine Feinberg School of Medicine in Chicago. She is also medical director of respiratory care at the Shirley Ryan AbilityLab, which provides care for more stroke, spinal cord injury and traumatic brain injury patients than anywhere else in the U.S. Her focus includes studying devices for ventilatory support used in home-based settings. This is most relevant to those with neuromuscular disorders and sleep-related breathing disorders. Dr. Wolfe earned her medical degree from The Ohio State University School of Medicine, and she completed a residency and fellowship at the McGaw Medical Center of Northwestern University. She is board-certified in pulmonary disease and sleep medicine by the American Board of Internal Medicine.


  1. American Academy of Sleep Medicine. AASM guidance in response to Philips recall of PAP devices. Updated Jan. 31, 2024.
  2. Wolfe L. 2018-19 Sleep medicine fellows webinar series. Case study on VAPS.
  3. Khan A, Frazer-Green L, Amin R, Wolfe L, et al. Respiratory management of patients with neuromuscular weakness: an American College of Chest Physicians clinical practice guideline and expert panel report. Chest. 2023 Aug;164(2):394-413.
  4. Coleman JM 3rd, Wolfe LF, Kalhan R. Noninvasive ventilation in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2019 Sep;16(9):1091-1098.
  5. Selim BJ, Wolfe L, Coleman JM 3rd, Dewan NA. Initiation of noninvasive ventilation for sleep related hypoventilation disorders: advanced modes and devices. Chest. 2018 Jan;153(1):251-265.