Talking Sleep – An AASM Podcast
Listen to Talking Sleep, a podcast of the American Academy of Sleep Medicine (AASM), for insightful discussions about the latest developments in the practice of clinical sleep medicine. Season five is now playing, and you can listen to the archived episodes from past seasons. Be sure to subscribe through your favorite podcast platform so you never miss a new episode.
We’d love to hear from you! Send your feedback and suggestions for Talking Sleep topics and guests to podcast@aasm.org.
Season Seven
Episode 1:
Understanding Residual AHI: What Sleep Doctors Need to Know
Welcome to Season Seven of Talking Sleep! In this episode, host Dr. Seema Khosla examines a crucial clinical question: how reliable is the residual AHI measured by PAP devices? Experts Dr. Robert Thomas, Dr. Tavi Ioachimescu, and Dr. Imran Iftikhar analyze the accuracy of PAP downloads, brand differences in measurement, and implications for patient care. Through meta-analysis findings and clinical research, they explore stable versus unstable breathing patterns and how this data influences treatment decisions.
The discussion covers device-specific algorithms, historical development of AHI measurement, and the role of patient monitoring software like OSCAR and SleepHQ. Learn about therapeutic approaches for unstable breathing, including medication options and practical management strategies for complex sleep apnea cases. (50:56) Listen now
Episode 2:
Sleep Apnea Detection: Inside the Apple Watch Algorithm
In this episode, host Dr. Seema Khosla explores the new Apple Watch sleep apnea screening algorithm with Dr. Matt Bianchi, a research scientist from Apple’s Health Technologies team. Learn about the innovative technology that monitors sleep patterns and potentially identifies sleep apnea risk through advanced wearable device capabilities.
Discover how this algorithm uses accelerometry and breathing disturbance detection to screen for potential sleep apnea, its limitations, and implications for patient care. The conversation delves into the algorithm’s performance, its role in consumer health technology, and guidance for sleep medicine professionals navigating new diagnostic tools. Whether you’re a clinician or interested in sleep health technology, this episode offers critical insights into the future of sleep disorder screening. (36:44) Listen now
Episode 3:
KPAP: Exploring a Novel PAP Therapy Approach
In this episode, host Dr. Seema Khosla explores KPAP, a groundbreaking PAP therapy innovation with Dr. David White, former AASM president, and Dr. William Noah, inventor of the V-com device. Learn about this new technology that promises to make positive airway pressure more comfortable and potentially more effective for sleep apnea patients.
Discover the science behind KPAP, its potential advantages over traditional CPAP, and how it addresses issues like treatment-emergent central apneas and CO2 rebreathing. The discussion covers the device’s development, clinical trial results, and implications for sleep apnea treatment, offering insights for clinicians and patients alike. (44:24) Listen Now
Episode 4:
Defining Well Treated Obstructive Sleep Apnea
In this episode, host Dr. Seema Khosla tackles a critical question in sleep medicine: What defines “well-treated” obstructive sleep apnea? Joined by Dr. Barry Krakow, a pioneering sleep medicine physician, the discussion explores the nuanced approach to assessing sleep apnea treatment beyond traditional metrics.
Discover insights into clinical endpoints for evaluating OSA treatment, the complex relationship between upper airway collapsibility and anxiety, and innovative strategies for patients with challenging sleep disorders. Dr. Krakow shares his unique perspectives on PAP therapy, including approaches for patients with PTSD and the potential role of behavioral interventions. (45:44) Listen Now
Episode 5:
Too Much of a Good Thing? Benefits of Lower Pap Settings
In this episode, host Dr. Seema Khosla explores a provocative question in sleep medicine: Could high pressure PAP therapy have unexpected inflammatory effects? Joined by Dr. Sanja Jelic from Columbia University and Dr. Daniel Gottlieb from Brigham and Women’s Hospital, the discussion examines emerging research that challenges conventional wisdom about positive airway pressure (PAP) therapy.
Discover groundbreaking findings on how PAP settings may influence inflammatory biomarkers like angiopoietin-2 (AP2) and VEGF-A, potentially explaining why cardiovascular outcomes in clinical trials haven’t consistently shown improvement with PAP therapy. Learn about pressure optimization strategies, alternatives to high-pressure PAP therapy, and implications for treating obstructive sleep apnea (OSA) in non-sleepy patients versus those with daytime sleepiness. (42:11) Listen Now
Episode 6:
Tirzepatide & OSA: Implementation for Sleep Clinics
In this episode, host Dr. Seema Khosla explores a transformative development in sleep medicine: the FDA approval of tirzepatide for obstructive sleep apnea (OSA). Joined by an expert panel including Dr. Atul Malhotra, lead investigator of the SURMOUNT-OSA trial, and specialists Dr. Radhika Breaden, Dr. Jeremy McConnell, and Dr. Rafael Sepulveda-Acosta, the discussion examines how sleep clinicians can effectively incorporate this groundbreaking medication into their treatment protocols.
Discover key insights about the SURMOUNT-OSA trial results published in the New England Journal of Medicine, including the mechanisms behind AHI improvement beyond weight reduction alone. Learn practical implementation strategies for private practices, including documentation requirements for insurance approval, necessary baseline labs, and optimal patient follow-up protocols. The experts address crucial questions about Medicare coverage, long-term medication management, the need for retesting at goal weight, and considerations for transitioning patients already using GLP-1 medications like Ozempic or Wegovy.
This episode provides essential guidance for sleep medicine specialists considering expanding their treatment options beyond traditional PAP therapy, including collaborations with obesity medicine clinics and whether obtaining board certification in Obesity Medicine would benefit sleep clinicians. This timely discussion equips practitioners with the knowledge to navigate the intersection of sleep medicine and obesity treatment in managing OSA patients. (47:27) Listen Now
Episode 7:
Decoding Women’s Sleep Health Across the Lifespan
In this episode, Dr. Seema Khosla talks with women’s sleep expert Dr. Safia Khan about women’s unique sleep challenges. Dr. Khan is an editor for A Clinical Casebook of Sleep Disorders in Women and specializes in women’s sleep health at UT Southwestern. She explains how sleep disorders affect women differently across their lives, particularly during pregnancy and menopause, and how these transitions disrupt normal sleep patterns.
Discover Dr. Khan’s assessment strategies for insomnia in women, including decision-making frameworks for implementing CBT-I versus medication interventions. Learn about the underdiagnosis of sleep disorders in women, particularly during menopause, and strategies for changing this normalized narrative. The conversation explores the physiological differences in sleep-disordered breathing between men and women, explaining why sleep apnea incidence equalizes during menopause.
The discussion addresses managing hypersomnia during pregnancy, approaches to fatigue without diagnosed sleep disorders, connections between PCOS and sleep disruption, and guidance on Restless Legs Syndrome management, including the critical role of iron deficiency screening in adolescent girls.
This episode provides essential knowledge for practitioners seeking to better understand and treat the unique sleep health challenges women face across their lifespans. Listen Now
Season Six
Season Five
Season Four
Season Three
Season Two
Season One

Our Host
Seema Khosla, MD, is board certified in internal medicine, pulmonary disease, critical care medicine, and sleep medicine. She works in Fargo, North Dakota, where she is the medical director of the North Dakota Center for Sleep.
Dr. Khosla is chair of the AASM Public Awareness Advisory Committee. She previously served on the AASM Task Force on Sleep Telemedicine, which developed a position paper for the use of telemedicine for the diagnosis and treatment of sleep disorders, and chaired the AASM Consumer and Clinical Technology Committee, which developed a position statement on the use of consumer sleep technology in clinical practice. Dr. Khosla also was co-chair of the AASM Sleep Medicine Trends course.
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