The Transformative Research Projects Program has been created under the auspices of the NIH Roadmap for Medical Research to enhance submission and support of exceptionally innovative, high risk, original and/or unconventional research that has the potential to have a profound impact in clinical, basic, and or behavioral/social science arenas.

NIH Roadmap Transformative Research Awards provide up to $25 million total costs per year for a single project. The NIH encourages applications for the Transformative Research Projects Program from scientists representing all disciplines relevant to the NIH mission. Interdisciplinary teams as well as individual investigators with bold ideas are encouraged to apply.

The deadline for submissions is Jan. 22, 2010, with Letters of Intent due by Dec. 22, 2009. See the instructions in the RFA on the NIH Web site. Additional information, including Frequently Asked Questions about the Transformative Research Projects Program, is available through the NIH Roadmap for Medical Research.  Send questions to