James P. Kiley, PhD, director of the National Heart, Lung, and Blood Institute (NHLBI) Division of Lung Diseases and former director (1995 – 2000) of the National Center on Sleep Disorders Research (NCSDR), focused on future opportunities and challenges in “Advancing respiratory research,” an article published in the August 2011 issue of CHEST.  Kiley notes that sleep and circadian biology is one of the potential frontiers to advance progress in respiratory biology in health and disease.