Season 7 | Episode 5
Dr. Sanja Jelic, Dr. Daniel Gottlieb | GUEST
In this episode, host Dr. Seema Khosla explores a provocative question in sleep medicine: Could high pressure PAP therapy have unexpected inflammatory effects? Joined by Dr. Sanja Jelic from Columbia University and Dr. Daniel Gottlieb from Brigham and Women’s Hospital, the discussion examines emerging research that challenges conventional wisdom about positive airway pressure (PAP) therapy.
Discover groundbreaking findings on how PAP settings may influence inflammatory biomarkers like angiopoietin-2 (AP2) and VEGF-A, potentially explaining why cardiovascular outcomes in clinical trials haven’t consistently shown improvement with PAP therapy. Learn about pressure optimization strategies, alternatives to high-pressure PAP therapy, and implications for treating obstructive sleep apnea (OSA) in non-sleepy patients versus those with daytime sleepiness.
Dr. Daniel J. Gottlieb is an Associate Professor of Medicine at Harvard Medical School and Brigham and Women’s Hospital, as well as Director of the Sleep Disorders Center at VA Boston Healthcare System. With over 30 years of experience, Dr. Gottlieb is a leading expert in sleep medicine research focusing on the cardiovascular consequences of obstructive sleep apnea. His groundbreaking research includes studies on CPAP versus oxygen therapy for sleep apnea treatment and recent work examining how PAP therapy may affect inflammatory biomarkers. Dr. Gottlieb has published extensively in prestigious journals including The New England Journal of Medicine and Circulation, and serves in leadership roles with the American Academy of Sleep Medicine, currently as Vice-chair of the Steering Committee for the Re-Envisioning OSA Characterization Task Force.
Dr. Sanja Jelic is a Professor of Medicine in the Division of Pulmonary, Allergy, and Critical Care Medicine at Columbia University in New York. She received her MD degree from the University of Zagreb, Croatia, and trained in internal medicine at the Albert Einstein College of Medicine, as well as in pulmonary, critical care, and sleep medicine at Columbia University. Her research focuses on the molecular mechanisms of endothelial dysfunction in disturbed sleep, including obstructive sleep apnea and sleep deprivation. Dr. Jelic was named Herbert Irving Professor at Columbia University and has received awards from the American Thoracic Society, American Academy of Sleep Medicine, and American Lung Association. Her work is funded by the NIH/NHLBI, American Heart Association, American Thoracic Society, and American Academy of Sleep Medicine, and she is the Director of the Center for Sleep Medicine at Columbia University Irving Medical Center.
Resources
- Peker Y, Celik Y, Behboudi A, Redline S, Lyu J, Wei Y, Gottlieb DJ, Jelic S. CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization. EBioMedicine. 2024 Mar;101:105015. DOI: 10.1016/j.ebiom.2024.105015
