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AASMMembershipSectionsNewsletter
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Issue #5
AmericanAcademy
of SleepMedicine
Effects of insufficient sleepon circadian rhythmicity
and expressionamplitudeof thehumanblood
transcriptome.
Moller-Levet,C. S.,Archer, S.N.,Bucca,G., Laing, E. E., Slak,
A.,Kabiljo,R., et al. (2013). ProcNatlAcadSciUSA, 110(12),
E1132-1141.
Insufficient sleep and irregular sleep-wakepatterns (including
circadianmisalignment) are associatedwithnumerousnegative
healthoutcomes. Nevertheless, little is known about the impact
of sleepdisturbanceon the clockgene system that likelyplays a
mechanistic role in thesepoor healthoutcomes. Furthermore, the
transcriptionproducts of these genes could serve as peripheral
biomarkers of disease risk. In this study, RNA expressionwas
measured inhealthy adults after aweekof 8.5hours of sleepper day
and a then again after aweekwhere sleepwas restricted to5.7hours
of sleepper day. Over 700geneswereup-or down-regulated after
insufficient sleep, and the circadian rhythms of gene expressionwere
blunted inmore than1000genes. Affectedgene systems included
genes known toplay a role inmetabolism andoxidative stress. This
paper sets the stage for futurework inunderstandingmechanisms
andmarkers of circadian rhythm and sleepdisruption’s effects on
health. (KMS)
