ScientificProgram | Wednesday
9:30am– 10:00am
Animal ModelsReplicate
Different InsomniaPhenotypes
Observed inHumans
GeorginaCano, PhD
S16:APerfect Time for
Chronomedicine
8:00am– 10:00am
RoomL100F
Co-chairs:
SabraAbbott, MD, PhD; andPhyllis Zee, MD,
PhD
Faculty:
SoniaAncoli-Israel, PhD; Brant Hasler, PhD; Till
Roenneberg, PhD; andFredTurek, PhD
Psychologist Level of Content:
Intermediate
Objectives:
1. Review thebroad roleof circadian dysfunction in
humanhealthand disease;
2. Discuss new techniques for diagnosing and treating
circadian disorders; and
3. Appreciate thepotential role for chronomedicine in
sleepmedicine.
8:00am– 8:25am
BasicCircadianScience:
Implications for Health
FredTurek, PhD
8:25am– 8:50am
DefiningCircadian andSleep
Health inPopulations
Till Roenneberg, PhD
8:50am– 9:15am
CircadianBasedApproaches to
ImproveTreatment Outcomes
SoniaAncoli-Israel, PhD
9:15am– 9:40am
CircadianRhythms in
PsychiatricDisorders
Brant Hasler, PhD
9:40am– 10:00am
Conclusion: The
ChronomedicineClinicModel
SabraAbbott, MD, PhD; and
Phyllis Zee, MD, PhD
S17:What isCataplexy?
8:00am– 10:00am
Room 205A
Chair:
Mehdi Tafti, PhD; andAnneVassalli, DPhil
Faculty:
Luis de Lecea, PhD; GiuseppePlazzi, MD;
ThomasScammell, MD; and JeromeSiegel, PhD
Psychologist Level of Content:
Advanced
Objectives:
1. Explain the conditions of high hypocretin/orexin
release in healthy subjects and increased propensity
of cataplexy in narcolepsy from both human and
animal investigations;
2. Review the phenomenology of the hypocretin/orexin
neural circuitry and its interactionswith other wake-
promoting pathways such as the noradrenergic
pathway; and
3. Analyze clinical and polysomnographic observations
of narcolepsywith cataplexywith developing
knowledge in the brain circuits underlying behavior,
and their alteration in absence of functional
hypocretin/orexin signaling.
8:00am – 8:20am
Introduction
Mehdi Tafti, PhD; andAnne
Vassalli, DPhil
8:20am – 8:45am
NeuronalActivity inCataplexy
JeromeSiegel, PhD
8:45am – 9:10am
ForebrainControl of Cataplexy
ThomasScammell, MD
9:10am – 9:35am
HumanCataplecticBehaviors
GiuseppePlazzi, MD
9:35am – 10:00am
OptogeneticControl of
MonoaminergicNuclei and
Cataplexy
Luis de Lecea, PhD
I10: Sleep andPediatricChronic
Pain: InnovativeApproaches to
Assessment andTreatment
9:05am – 10:05am
Room 101E
TonyaPalermo, PhD (Bio on page 32)
Psychologist Level of Content:
Intermediate
Objectives:
1. Summarize the evidence for sleep disturbances in
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